Preemptive analgesia

Activation of nociceptive pathways leads to peripheral and central sensitization and to hyperalgesia. Peripheral sensitization is mediated by prostaglandins and other inflammatory mediators, while central sensitization involves activation of W-methyl-D-aspartate (NMDA) receptors, resulting in 'wind-up' (lowering of thresholds for subsequent noxious stimuli and expansion of neuronal receptive fields). Experimental studies suggest that this sensitization can be prevented or reduced by treatment before the stimulus with antiprostaglandins, intravenous opioids, intraspinal opioids or local anesthetics, or peripheral nerve block. The benefits often last longer than the duration of action of a local anesthetic (Wo.o.li..ยง.D.d C.h.PD.g...l9.9.3.).

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

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