Phosphodiesterase inhibitors

The mechanism of action of these drugs is inhibition of phosphodiesterase in the heart and vascular wall with accumulation of cAMP. These 'inodilators' increase myocardial contractility without a major rise in heart rate or myocardial oxygen demands, and produce a fall in peripheral vascular resistance without a major blood pressure lowering effect. They increase cardiac compliance and have a prolonged duration of action. They can be used judiciously, mainly as an adjunct to standard therapy in patients in whom cardiac output is (relatively) low, for instance during postmyocardial infarction shock and after cardiopulmonary bypass surgery. Severe hypotension does not usually occur but can be a major limitation in some patients.

Kicking Fear And Anxiety To The Curb

Kicking Fear And Anxiety To The Curb

Kicking Fear And Anxiety To The Curb Can Have Amazing Benefits For Your Life And Success. Learn About Calming Down And Gain Power By Learning Ways To Become Peaceful And Create Amazing Results.

Get My Free Ebook


Post a comment