Pharmacokinetics

Almitrine bismesylate is highly lipid soluble and is absorbed from the gut in 2 to 3 h and highly bound to albumin in the circulation. The plasma half-life is about 2 days. Almitrine is mostly lost through bile and is not excreted in the urine. The physiological effect of a single dose lasts for approximately 6 h. Few adverse reactions have been reported in short-term use; they include headache, urticaria, diarrhea, chest pain, nausea, and vomiting. The most significant side-effect is possible sensory neuropathy in long-term use, already noted above.

Sleep Apnea

Sleep Apnea

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