Paralysis

In the early period following intubation and mechanical ventilation, muscle relaxants may be needed to supplement sedation to minimize peak inspiratory pressures. Vecuronium is recommended as it does not release histamine. Patients receiving prolonged non-depolarizing neuromuscular blockade over several days, particularly in combination with corticosteroids, may experience significant skeletal muscle wasting. This myopathy is usually fully reversible over weeks but may delay ventilator weaning.

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