Overt bleeding

The common odds ratios demonstrated clear superiority of one regimen over another in two comparisons (Table 1). H2-receptor antagonists (common odds ratio,

0.42; 95 per cent confidence interval, 0.27-0.60) reduce overt bleeding compared with placebo or no therapy. Three comparisons showed substantial trends which, nevertheless, may still be attributable to chance. Antacids appeared to reduce overt bleeding compared with placebo or no therapy (common odds ratio, 0.63; 95 per cent confidence interval, 0.35-1.11). H2-receptor antagonists tended to be more effective in reduction of overt bleeding than did antacids (common odds ratio, 0.69; 95 per cent confidence interval, 0.44-1.06). The pooled analysis showed a trend of similar magnitude in favor of sucralfate over H 2-receptor antagonists (common odds ratio, 0.81; 95 per cent confidence interval, 0.44-1.47). A final analysis suggested the equivalence of sucralfate and antacids in the prevention of overt bleeding (common odds ratio, 0.96; 95 per cent confidence interval, 0.54-1.70).

Table 1 Randomized trials of stress ulcer prophylaxis

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