Other sedatives

Barbiturates are not often administered for sedation in critically ill patients because they depress the cardiovascular and respiratory systems. In some special indications, for example treatment of elevated intracranial pressure, barbiturates are used with varying degrees of success.

Indications for haloperidol and other butyrophenone neuroleptics are delirium, psychoses, and withdrawal syndromes. In addition to the well-known neuroleptic side-effects, haloperidol may cause QT prolongation on the ECG and therefore should be used with caution, particularly when other drugs known to prolong the QT interval are used. Haloperidol dose rates may reach up to 25 mg/h.

Clonidine is a centrally acting imidazoline and a 2-agonist. It can be used as an alternative or addition to benzodiazepines in the treatment of severe alcohol withdrawal symptoms or delirium, which are accompanied by profound activation of the sympathetic nervous system. In these patients, even very high doses of clonidine (up to 5000 pg/day) do not cause relevant hypotension.

Preliminary reports suggest that isoflurane, a volatile anesthetic agent, can be used for short- and long-term sedation in patients requiring mechanical ventilation. The main advantages of this approach are rapid onset of action, easy titration, and fast dissipation of the effect. Major disadvantages are the need for expensive additional equipment and unavoidable temporary interruptions of the ventilator circuit, for example when the patient is transferred.

Booze Basher

Booze Basher

Get All The Support And Guidance You Need To Permanently STOP The Battle With Alcohol Once And For All. This Book Is One Of The Most Valuable Resources In The World When It Comes To Transformational Tools For Battling Booze Binges And Staying Alcohol-Free.

Get My Free Ebook

Post a comment