Other medications under evaluation

Calcium-induced injury is central to neurocellular damage. Nimodipine, a calcium-channel antagonist, has been shown to have no overall efficacy, although it may be effective in a subgroup of patients with traumatic subarachnoid hemorrhage.

Steroids in high doses have not been shown to be effective and their administration is not recommended since they contribute to morbidity.

21-Amino steroids are much more potent antioxidants without any hormonal effects. They inhibit iron-dependent lipid peroxidation, thus preventing free-radical production. Tirilizad mesylate is undergoing phase III prospective evaluation.

Polyethylene glycol superoxide dismutase is an oxygen free-radical scavenger. Phase II clinical trials have shown safety and efficacy, although a recent unpublished phase III trial in the United States failed to confirm initial findings.

In situations where conventional ICP control has failed, reducing transcapillary pressure with dihydroergotamine as a precapillary vasoconstrictor and with systemic hypotensive agents while maintaining colloid oncotic pressure with albumin has led to improved mortality compared with a matched historical control group.

Sleep Apnea

Sleep Apnea

Have You Been Told Over And Over Again That You Snore A Lot, But You Choose To Ignore It? Have you been experiencing lack of sleep at night and find yourself waking up in the wee hours of the morning to find yourself gasping for air?

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