Nucleotides form part of the normal diet but are absent from standard enteral feeds. They can be synthesized from glutamine, but considerable upregulation of this pathway is needed if the body's needs are to be satisfied in the absence of dietary intake. In vitro experiments show that human enterocyte growth is stimulated by purines or pyrimidines, but only when the supply of glutamine is limited. Similar effects have been shown in lymphocytes. Experimental studies have demonstrated a link between dietary nucleotide restriction and mortality from infection. In humans, the bacteria dying in the bowel lumen would normally provide larger amounts of nucleotide than the content of 'nucleotide-supplemented' enteral feeds, and improved patient outcome has not yet been shown.

Gaining Weight 101

Gaining Weight 101

Find out why long exhausting workouts may do more harm than good. Most of the body-building workout and diet regimens out there are designed for the guys that gain muscle and fat easily. They focus on eating less and working out more in order to cut the excess fat from their bodies while adding needed muscle tone.

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