Organic nitrates such as isosorbide dinitrate and isosorbide mononitrate are available in many preparations. Headache may limit acceptability. Long-acting nitrates should be given in a regimen which allows a nitrate-free period at the time of day that fewest episodes of angina occur. The nitrate-free period reduces the development of tolerance. Nitroglycerin (glyceryl trinitrate) is still used sublingually as a spray or tablet to terminate episodes of angina or as prophylaxis before angina-provoking exertion.

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