Neuromuscular junction

This is involved in myasthenia gravis, myasthenic syndromes, and following administration of depolarizing and non-depolarizing muscle relaxants. Muscle

In primary muscle diseases weakness is usually proximal and symmetrical. Inflammatory myopathies (polymyositis, dermatomyositis) and some metabolic disorders (McArdle's disease, carnitine palmityl transferase deficiency) are usually accompanied by muscle pain and weakness, but many other primary disorders of muscle are painless. The myopathy associated with myxedema often causes muscle pain, and muscle tenderness is common in Guillain-Barre syndrome. The reflexes are usually preserved in myopathies unless wasting is severe, as in advanced Duchenne muscular dystrophy.

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