Morphine

Morphine is widely used in critical care. Glucuronidation of morphine produces two metabolites, morphine-3-glucuronide and morphine-6-glucuronide.

The concentrations of morphine-3-glucuronide and morphine-6-glucuronide may be up to 10 times and 100 times respectively the concentration of morphine in the plasma. Morphine-3-glucuronide tends to antagonize morphine, and morphine-6-glucuronide is up to 10 times more effective than morphine in tests of analgesia. The metabolites depend on glomerular filtration and accumulate in renal failure. This is a significant drawback in critical care patients as it may result in prolonged weaning, increased morbidity, and increased costs. Multicompartmental pharmacokinetic data are not available for morphine. Following titration (front-loading), the elimination half-life (approximately 3 h) is used to calculate the approximate infusion rate as the dose of morphine required in a 3-h period is half the front-loading dose. Suboptimal analgesia requires retitration as adjustment of the infusion alone requires four to five half-lives to steady state.

Healthy Fat Loss For A Longer Life

Healthy Fat Loss For A Longer Life

What will this book do for me? A growing number of books for laymen on the subject of health have appeared in the past decade. Never before has there been such widespread popular interest in medical science. Learn more within this guide today and download your copy now.

Get My Free Ebook


Post a comment