Miscellaneous drugs

Hydralazine, diazoxide, and phentolamine can be administered continuously and also as a bolus, since the blood-pressure-lowering effect may be relatively prolonged. The ganglion blocker trimetaphan is used for the treatment of aortic dissection and for controlled hypotension during surgery. This drug, which is continuously intravenously infused, acts rapidly and has a short duration of action. It competitively inhibits the action of acetylcholine at autonomic ganglia, thereby blocking sympathetic and parasympathetic pathways. Thus the hypotensive effect is not accompanied by a baroreceptor-mediated reflex tachycardia.

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