MHC molecules interact with both the T-cell receptor and the coreceptor molecules CD4 and CD8 on the T-cell surface. Since CD8 interacts only with class I MHC, and CD4 only with class II MHC, and furthermore mature T cells express only CD4 or only CD8, this results in the creation of two classes of T cells recognizing different processed sets of antigen. Class-I-specific CD8 T cells are the major component of cellular cytotoxicity, while CD4 cells are the key cells regulating the immune response.
Was this article helpful?
What will this book do for me? A growing number of books for laymen on the subject of health have appeared in the past decade. Never before has there been such widespread popular interest in medical science. Learn more within this guide today and download your copy now.