Lowmolecularweight heparin

Low-molecular-weight heparins cannot be monitored adequately by activated partial thromboplastin time, activated coagulation time, whole-blood clotting time, or thrombin time because of their high ratio of anti-Xa to anti-IIa activities. A prolonged activated partial thromboplastin time is indication of overdose; therefore an anti-Xa assay should be employed.

For deep vein thrombosis prophylaxis 2500 IU is given subcutaneously every 12 h. For anticoagulation of an extracorporeal circuit a bolus of 35 IU/kg is given intravenously followed by an infusion of 13 IU/kg. The dose is adjusted to maintain anti-Xa activity at 0.5 to 1 IU/ml (or 0.2 to 0.4 IU/ml if there is a high risk of hemorrhage).

Was this article helpful?

0 0
Sleep Apnea

Sleep Apnea

Have You Been Told Over And Over Again That You Snore A Lot, But You Choose To Ignore It? Have you been experiencing lack of sleep at night and find yourself waking up in the wee hours of the morning to find yourself gasping for air?

Get My Free Ebook

Post a comment