Key messages

• Pulmonary hypertension is often secondary to other cardiopulmonary diseases.

• Acute pulmonary hypertension is ameliorated by treatment of the underlying disease.

• Chronic pulmonary hypertension results in vascular remodeling.

• Recovery from chronic pulmonary hypertension is possible and depends on vascular endothelial integrity.

• The prognosis of primary pulmonary hypertension is generally fatal.

• Therapy is focused on a reduction in pulmonary artery pressures and the prevention of right ventricular dysfunction or failure.

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