Key messages

• Lack of therapeutic response or development of side-effects with one selective serotonin reuptake inhibitor does not necessarily predict the same outcome with another.

• The selection of an antidepressant should be based on the side-effect profile of the drug and the type of depressive disorder.

• When the patient recovers from a depressive episode, maintenance treatment should be considered to reduce the significant risk of relapse associated with major depression.

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