Key messages

• Until a direct methodology to diagnose capillary leak is developed, it is impossible to know whether patients with edema and low pulmonary artery wedge pressure have a quickly resolving capillary injury or slowly resolving hydrostatic edema.

• The use of positive end-expiratory pressure remains the most important therapeutic modality.

• Mortality remains high in non-cardiogenic pulmonary edema, emphasizing the fact that it is a mere reflection or symptom of multiorgan disease.

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