Key messages

• The three basic mechanisms of the disease process of asthma are airway wall inflammation, smooth-muscle-mediated bronchoconstriction, and intraluminal mucus. Therefore therapy must include aggressive utilization of anti-inflammatory medications and bronchodilators.

• Maximal bronchodilator and supportive therapy should be provided under the highest level of observation and monitoring in an intensive care or high-dependency unit.

• Mechanical ventilation is indicated in the asthmatic who continues to deteriorate despite maximal medical therapy.

• The aim of mechanical ventilation is to maintain adequate arterial oxygenation and control acidosis while specific therapeutic measures reverse bronchospasm, reduce bronchial epithelium inflammation, mobilize secretions, and suppress airway hyper-reactivity.

• Deterioration despite optimal treatment, including oral steroids and accelerated use of inhaled b-agonists, identifies patients at higher risk for fatal asthma. A history of near-fatal asthma requiring mechanical ventilation is the greatest single predictor of subsequent asthma death.

Healthy Fat Loss For A Longer Life

Healthy Fat Loss For A Longer Life

What will this book do for me? A growing number of books for laymen on the subject of health have appeared in the past decade. Never before has there been such widespread popular interest in medical science. Learn more within this guide today and download your copy now.

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