Key messages

• Oxygen toxicity is mediated by reactive oxygen species, including superoxide, hydrogen peroxide, and hydroxyl radicals.

• Enzymatic and low-molecular-weight antioxidants protect cells from reactive oxygen species, but can be overwhelmed in hyperoxia.

• Arterial hypoxemia due to extreme V/Q mismatching (intrapulmonary shunt) requires high levels of inspired oxygen.

• Pulmonary oxygen toxicity resembles acute respiratory distress syndrome in its pathophysiology and morphology.

• Many drugs used clinically, including chemotherapeutic agents and corticosteroids, may exacerbate pulmonary oxygen toxicity.

• No clinically available agents (with the possible unproved exception of surfactants) mitigate human manifestations of oxygen toxicity.

Sleep Apnea

Sleep Apnea

Have You Been Told Over And Over Again That You Snore A Lot, But You Choose To Ignore It? Have you been experiencing lack of sleep at night and find yourself waking up in the wee hours of the morning to find yourself gasping for air?

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