Key messages

• The components that distinctively determine P02 and PC02 in any single gas exchange unit of the lung are the VpJQ ratio, the composition of the inspired gas, and the composition of the mixed venous blood.

• The multiple inert gas elimination technique gives both quantitative and qualitative estimates of the distributions of VA/Q ratios.

• If the measured PaO2 is significantly different from the values estimated using the multiple inert gas elimination technique, other potential mechanisms of hypoxemia, such as diffusion limitation to O2, increased intrapulmonary parenchymal O2 consumption, or increased postpulmonary shunt are implicated.

Sleep Apnea

Sleep Apnea

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