Key messages

• The majority of deaths in patients who have been critically ill for more than 7 days are associated with sepsis.

• Critical illness is associated with multiple defects in immune function which reduce the capacity to fight infection.

• Immune dysfunction can be related both to excess production of proinflammatory mediators and, at other times, to overproduction of endogenous anti-inflammatory agents.

• Cytokines are not the only soluble factors implicated in the generation of immune dysfunction; eicosanoids, reactive oxygen intermediates, heat shock proteins, and acute phase reactants are also important.

• Hormonal, nutritional, and genetic factors, as well as associated organ failures (renal—uremia; gut—endotoxin/translocation; respiratory—hypoxia) and drugs, all contribute to impairment of normal immune function in critically ill patients.

Was this article helpful?

0 0
Sleep Apnea

Sleep Apnea

Have You Been Told Over And Over Again That You Snore A Lot, But You Choose To Ignore It? Have you been experiencing lack of sleep at night and find yourself waking up in the wee hours of the morning to find yourself gasping for air?

Get My Free Ebook

Post a comment