Key messages

• Bacterial meningitis is the most common form of serious intracranial infection.

• Over 75 per cent of cases occur in children under 15 years of age.

• Pathogenic organisms colonize the nasopharyngeal mucosa of a susceptible host.

• The cerebrospinal fluid inflammatory response is responsible for most of the deleterious effects of the infection.

• Understanding this response has allowed a more rational approach to therapy.

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