Key messages

• Hypoglycemia is most frequently due to glucose production that is inadequate to meet metabolic demands.

• The central nervous system is dependent on serum glucose for fuel needs and the body normally has an intricate system for maintaining serum glucose within a tight range.

• The most common reason for loss of glucose control is the effects of drugs including insulin, other hypoglycemic drugs, and ethanol.

• Organ failure is another cause of hypoglycemia in hospital patients. This is usually due to massive failure of the liver.

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