Key messages

• Legionella is the most common pathogen causing life-threatening atypical pneumonia.

• Micro-organisms involved in atypical pneumonia are capable of:

resisting phagocytosis (Mycoplasma pneumoniae);

creating abnormal phagosomes which do not fuse with secondary lysosomes (Legionella species);

surviving within phagocytes by inhibiting phagolysosomal fusion ( Chlamydia pneumoniae, Mycobacterium tuberculosis);

resisting lysosomal enzymes (Coxiella burnetii, Mycobacterium tuberculosis).

• The main defense against these infections is the cellular immune response.

• Essentially, any virus can produce any syndrome, but severe pneumonia in adults leading to admission to the intensive care unit is usually due to influenza and herpes viruses (varicella zoster virus).

Healthy Fat Loss For A Longer Life

Healthy Fat Loss For A Longer Life

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