Key messages

• The agents currently available for the prevention of seizures do not interfere with the development of epilepsy.

• The major categories of antiseizure agents include hydantoins, benzodiazepines, barbiturates, and propofol.

• Benzodiazepines are frequently preferred for active seizure termination, while hydantoins are most useful for prophylaxis against subsequent seizures.

• Propofol, high-dose benzodiazepines, and high-dose barbiturates are most useful for the management of refractory status epilepticus.

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