Key messages

• Thyroid hormones act on most tissues in the organism via nuclear T3 receptors.

• Biological actions vary depending on the target cell. The main actions are influence on cell growth and maturation (central nervous system, bone) and modulation of metabolism (carbohydrates, lipids, proteins, drugs).

• Thyroid hormones are thermogenic agents, stimulating respiratory oxygen consumption and heat production. The latter is important in hypothyroidism, mainly in myxedema coma.

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