Isoflurane (CF3-CHCl-O-CHF2) is a methyl ethyl ether and an isomer of enflurane. It has a lower blood-gas partition coefficient than halothane or enflurane which allows the alveolar concentration to rise rapidly towards the inspired concentration, leading to a rapid induction of sedation. The level of consciousness can be controlled with precision. The effective dose for sedating ventilated patients is confined to a narrow range (0.1-0.4 per cent). Recovery after prolonged isoflurane sedation is rapid, allowing early extubation and mobilization ( Spencer and Willatts 19.9.2.).
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