Introduction

Liver disease is common. It may be the reason for admission to the intensive care unit (ICU), for example after a paracetamol overdose. Alternatively, it may develop in the ICU, complicating another illness such as sepsis. Finally, patients may have a chronic disease complicated by another illness or an acute exacerbation.

There are several problems caused by hepatic failure which will influence the use of drugs ( Fig 1).

Fig. 1 Some of the many factors affecting pharmacodynamics and pharmacokinetics in liver failure.

Sleep Apnea

Sleep Apnea

Have You Been Told Over And Over Again That You Snore A Lot, But You Choose To Ignore It? Have you been experiencing lack of sleep at night and find yourself waking up in the wee hours of the morning to find yourself gasping for air?

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