There have been no randomized controlled trials of the treatment of human anaphylaxis. The unpredictable onset, variable severity, and priority and effectiveness of treatment make such studies impossible. Therefore the treatment of anaphylaxis is based on cellular mechanisms, animal models, and clinical observation. The understanding of the use of epinephrine (adrenaline), the role of steroids, and the appreciation of the need for volume replacement were poor in a review of 105 anaphylactic reactions to bee stings.
Was this article helpful?