Tricyclic antidepressants are likely to be taken in overdose by patients under treatment for depression, and are the most common cause of intensive care unit (ICU) admission for poisoning in most Western countries. The older tricyclic drugs, such as amitriptyline and dothiepin, are particularly toxic in overdose. Although the mechanism of tricyclic toxicity is now well understood, there have been few practical therapeutic advances in its management and good supportive care remains the mainstay. Non-tricyclic drugs are generally less toxic in overdose, although the monoamine oxidase inhibitors may cause a hyperthermic syndrome.

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