Indications for platelet transfusion

1. Thrombocytopenia:

a. bone marrow failure (hematological malignancy, post-chemotherapy, aplastic anemia);

b. disseminated intravascular coagulation (DIC);

c. massive transfusion;

d. immune thrombocytopenia (only in severe bleeding).

2. Platelet dysfunction:

a. congenital (rare);

b. acquired (cardiopulmonary bypass surgery, drug induced (aspirin), uremia).

Platelet transfusions are contraindicated in thrombotic thrombocytopenic purpura, hemolytic uremic syndrome, and heparin-induced thrombocytopenia because the underlying tendency is for thrombosis rather than bleeding.

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