Indications for administration of fresh frozen plasma

These have been summarized as follows by the British Committee for Standards in Hematology.

1. Definite indications:

a. replacement of factor deficiency where specific factor concentrate is not available (e.g. factors V, X);

b. immediate reversal of warfarin effect;

c. vitamin K deficiency;

e. thrombotic thrombocytopenic purpura.

2. Conditional uses—fresh frozen plasma indicated if there is bleeding and disturbed coagulation (prothrombin time or activated partial thromboplastin time more than 1.5 times control value):

a. massive transfusion;

b. liver disease;

c. cardiopulmonary bypass surgery;

d. special pediatric indications.

There is no justification for the use of fresh frozen plasma in hypovolemia, plasma exchange procedures (except in thrombotic thrombocytopenic purpura), formula replacement, nutritional support, or treatment of immunodeficiency states.

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