Immunosuppression and prevention of rejection

Cyclosporine A (cyclosporin A) has been fundamental to the success of liver transplantation, as with other solid organs. It inhibits T-cell-mediated production of interleukin 2 (IL-2). T suppressor cells are spared, enhancing natural immunosuppression. Triple therapy (cyclosporine A, azathioprine, prednisolone) is usually started within 12 h postoperatively. Some centers start cyclosporine A preoperatively. Daily cyclosporine A levels are required in the early postoperative period, to avoid both subtherapeutic levels and toxicity such as renal failure, neurological complications, and hepatatoxicity mimicking allograft rejection. However, early rejection remains the most common cause of hepatic dysfunction after orthotopic liver transplantation, with at least one rejection episode occurring in two-thirds of recipients. The dose of cyclosporine A should be reduced or its introduction delayed in patients with evolving renal dysfunction.

Sleep Apnea

Sleep Apnea

Have You Been Told Over And Over Again That You Snore A Lot, But You Choose To Ignore It? Have you been experiencing lack of sleep at night and find yourself waking up in the wee hours of the morning to find yourself gasping for air?

Get My Free Ebook

Post a comment