Immunosuppression and AIDS

Similar arguments for early 'blind' anti-infective therapy apply in patients immunosuppressed for other reasons, such as transplant recipients or those receiving steroid therapy. Transplant recipients often have impaired cell-mediated immunity and may be more susceptible to fungal, protozoal, or viral infection in addition to bacterial sepsis. A variety of opportunistic infections, such as Pneumocystis carinii pneumonia, cytomegalovirus infection, or Mycobacterium intracellulare avium infection, may cause fever in patients with AIDS, and these require investigation and treatment.

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