Hyoscine Nbutylbromide Buscopan

Buscopan acts as a smooth muscle antispasmodic by inhibiting the action of acetylcholine at postganglionic parasympathetic neuromuscular junctions. It does not cross the blood-brain barrier and therefore is devoid of central nervous system effects.

Dosage and pharmacokinetics

Buscopan is poorly absorbed from the gastrointestinal tract (< 10 per cent) and in the acute situation is normally given parenterally (intravenous, intramuscular, or subcutaneous) at a dose of 20 mg (for an adult), repeated as required. It has low plasma protein binding and is metabolized by the liver.

Adverse effects and drug interactions

Side-effects are mainly those of peripheral parasympathetic blockade and, although these are less marked than with atropine, Buscopan should not be administered to patients with paralytic ileus, glaucoma, or prostatic hypertrophy.

Use in critical care

Buscopan is commonly used to reduce smooth muscle spasm particularly during upper or lower gastrointestinal tract endoscopy. It is also used to treat the acute smooth muscle spasm of biliary and renal colic.

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Baby Sleeping

Baby Sleeping

Everything You Need To Know About Baby Sleeping. Your baby is going to be sleeping a lot. During the first few months, your baby will sleep for most of theday. You may not get any real interaction, or reactions other than sleep and crying.

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