Goodness of fit of the model

The first application of a model should be to test its fit on a sample of patients independent of the sample used to develop it. The sample of patients used to test the method should be a completely new cohort.

Often, a large sample of patients is randomly split and one portion is used to develop the method and the second portion is used to test the method. However, given that the random split of the sample of patients ensures that the characteristics of the patients in each subset are similar, such testing tends to overestimate the goodness of fit of the model.

The goodness of fit is tested by examining its calibration and discrimination ( Hosmle^..and...lLeml§shgw...1989).

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