Ganciclovir

Ganciclovir is more active than acyclovir against cytomegalovirus. It is usually administered parenterally and penetrates the lung and liver. Dose should be reduced in renal failure, but it is removed by hemodialysis. Ganciclovir is used to treat cytomegalovirus retinitis in AIDS patients and is also effective in cytomegalovirus gastrointestinal disease. The presence of cytomegalovirus in the lungs of AIDS patients may not be the cause of clinical disease and is usually not treated. Ganciclovir does not affect outcome in cytomegalovirus pneumonitis in transplant recipients unless given with immunotherapy. Myelosuppression is common, and mucositis, fits, and rash can occur.

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