Fibrinolytic system

Fibrinolysis (like coagulation) is a normal hemostatic response to vascular injury. Plasminogen, a b-globulin proenzyme in blood and tissue fluid, is converted to plasmin by tissue plasminogen activator released from endothelium by stimuli such as thrombin, trauma, exercise, and venous stasis. Once released, tissue plasminogen activator binds to fibrin and converts thrombus-bound plasminogen into plasmin, thus localizing fibrinolysis to the blood clot. Plasmin splits both fibrin and fibrinogen, producing a variety of fibrin degradation products. The activity of plasmin is balanced by several physiological inhibitors, the principal one being a2-antiplasmin. Two common therapeutic inhibitors of plasmin are e-aminocaproic acid and tranexamic acid. In contrast, the fibrinolytic agent streptokinase forms complexes with plasminogen and enhances plasmin production.

Sleep Apnea

Sleep Apnea

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