Eradication of the organism

Wound care

Once human tetanus immunoglobulin has been given, the infected site (if found) should be thoroughly cleaned and all necrotic tissue should be extensively debrided. Antibiotics

Although questionable, antibiotics are administered to eradicate the vegetative toxin-producing forms of C. tetani. Recommended antibiotic regimens include the following:

1. metronidazole 500 mg intravenously every 6 h for 10 days;

2. benzylpenicillin (penicillin G) 0.6 to 1.8 g intravenously every 6 h for 10 days (NB penicillin, a GABA antagonist, may aggravate the spasms);

3. erythromycin or clindamycin are alternatives.

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