Isoflurane is a good sedative and avoids the problems associated with multiple intravenous infusions such as venous access, incompatibility of solutions, risk of infection, and the dangers associated with bolus adminstration. It requires a vaporizer which is accurate at low inspired concentrations, obviating the need for an expensive monitor to measure the inspired and expired concentrations. For safety the maximum inspired concentration should be 1 per cent with increments of 0.1 per cent. For ease of use and convenience the vaporizer should be portable and compatible with any ventilator and breathing circuit. A Penlon OMV drawover vaporizer with all these features has now been developed specifically for ICU use and is accurate down to an inspired concentration of 0.1 per cent.
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