Enhanced elimination

Because tricyclic antidepressants have a large volume of distribution and enterohepatic recirculation accounts for only 15 per cent of their elimination, repeated doses of charcoal are unlikely to have a significant effect. A further dose of charcoal (50 g in adults) after 2 to 4 h should be considered only in large overdoses or with sustained release preparations. Diuresis, hemodialysis, and hemoperfusion are ineffective and are not recommended for elimination of tricyclic antidepressants.

Anxiety and Depression 101

Anxiety and Depression 101

Everything you ever wanted to know about. We have been discussing depression and anxiety and how different information that is out on the market only seems to target one particular cure for these two common conditions that seem to walk hand in hand.

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