Endogenous cryogens

Cytokines do not always elevate body temperature. Several peptides reduce the thermoregulatory set-point; these are known as endogenous cryogens. Putative endogenous cryogens include a-melanocyte-stimulating hormone, AVP, and several inhibitors of proinflammatory cytokines. In addition, tumor necrosis factor, normally considered a 'proinflammatory' cytokine, may also act as an endogenous cryogen. Such mediators may be functionally significant; for example, there is evidence that some of the action of salicylates, in addition to their inhibition of cyclo-oxygenase, may be partially mediated by release of endogenous AVP.

Was this article helpful?

0 0
Sleep Apnea

Sleep Apnea

Have You Been Told Over And Over Again That You Snore A Lot, But You Choose To Ignore It? Have you been experiencing lack of sleep at night and find yourself waking up in the wee hours of the morning to find yourself gasping for air?

Get My Free Ebook

Post a comment