The optimum dosage and scheduling of intravenous immunoglobulin depends on the clinical indication and specific preparation. The recommended replacement dose for primary immunodeficiency is 0.1 to 0.4 g/kg/month depending on the degree of antibody production failure and the risk of infection. Larger doses are required for autoimmune diseases such as acute immune thrombocytopenic purpura, and these vary from 0.4 to 1 g/kg/day for 2 to 5 days depending on the clinical response. In demyelinating neuropathies, 0.4 to 1 g/kg/day is administered for 5 days.
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