Cutaneous changes have been the classic feature of hypothyroidism ever since the first description of myxedema by Ord in 1878. Peripheral vasoconstriction and decreased cutaneous metabolism are expressed as a cold, dry, and pale skin. The accumulation of mucopolysaccharides and proteins in the interstitial spaces of the skin induces thinning of the epidermis and deep wrinkles ( NiC0.^0.ff,§n.d.,Lo.P.[§.sti 1993). Hair is scarce, with slow growth. Only 40 per cent of hypothyroid patients have typical cutaneous infiltration.
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