Dermatological changes

Cutaneous changes have been the classic feature of hypothyroidism ever since the first description of myxedema by Ord in 1878. Peripheral vasoconstriction and decreased cutaneous metabolism are expressed as a cold, dry, and pale skin. The accumulation of mucopolysaccharides and proteins in the interstitial spaces of the skin induces thinning of the epidermis and deep wrinkles ( NiC0.^0.ff,§n.d.,Lo.P.[§.sti 1993). Hair is scarce, with slow growth. Only 40 per cent of hypothyroid patients have typical cutaneous infiltration.

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