Creatinine clearance UVIS

where U (pmol/ml) is the urine creatinine concentration, V (ml/min) is the urinary volume, and S (pmol/ml) is the serum creatinine level.

Measuring creatinine clearance obviates some of the problems of using serum creatinine as a marker of glomerular filtration rate, but creates others. The above equation assumes that serum creatinine is constant over 24 h. This may not be valid under clinical conditions. Differences in muscle mass do not affect clearance, but variability in tubule secretion of creatinine does. Tubule secretion causes creatinine clearance to overestimate the true glomerular filtration rate.

It can be questioned whether measurement of clearance gives more reliable information than serum creatinine level alone.

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