Conclusions

The clinical course and prognosis of pulmonary hypertension is mainly determined by successful cessation of the disease process. Increased pulmonary blood flow, hypoxic vasoconstriction, elevated left ventricular preload, and increased pressure are factors which promote vascular remodeling in acute pulmonary hypertension. While acute pulmonary hypertension, for example during sepsis or acute respiratory failure, is relieved with the cure of the underlying disease, persistent pulmonary hypertension leads to intimal hypertrophy and endothelial alterations. Provided that endothelial integrity remains, recovery from pulmonary hypertension is possible. Recovery may take years and depends on hemodynamic alterations to the whole pulmonary circulation, including the right and left ventricles. If pulmonary hypertension is secondary to immunological or metabolic processes and obliteration or destruction of the vascular texture occurs, the disease process is rarely reversible. Outcome is eventually fatal, particularly in primary pulmonary hypertension, and therapy is mainly restricted to symptom relief. Right ventricular failure is the main cause of death in endstage pulmonary hypertension.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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