Clonidine ACE inhibitors

Captopril Enalapril Lisinopril Beta-blockers Atenolol Esmolol Labetalol Metoprolol Propranolol Sotalol Diazoxide Hydralazine Nitroprusside Antiarrhythmic agents Adenosine Amiodarone Bretylium

Lidocaine (lignocaine) Procainamide Propafenone Calcium-channel blockers Amlodipine Diltiazem Nimodipine Verapamil Cardiac glycosides Digitoxin Digoxin Diuretics Acetazolamide Bumetanide

50-100 mg 50-150 pg/kg/min 200-600 mg 50-100 mg 80-160 mg 160 mg

150-300 mg bolus 25-50 mg 0.25-8.0 pg/kg/min

3-6 mg IV bolus 800-2000 mg 5-30 mg/kg 50 mg over 2 min 350-400 mg 150-300 mg

Twice daily 100%

100%

Every 8 h Every 12 h Every 24 h

Every 24 h By infusion Twice daily Twice daily Twice daily Every 24 h

Three times daily By infusion

Load Load

Repeat every 5min*3 Every 3-4 h Every 8 h

Every 24 h Every 8 h Every 8 h Every 8 h

Every 24 h Load

100% every 24 h 100% 100% 100% 100% 100% 100% Every 8 h 100%

100%

100% every 24 h

50% every 48 h 100% 100% 100% 100% 30% 100% Every 8 h 100%

Every 6-12 h 100%

100%

30%-50% every 96 h 100% 100% 100% 100% 15%-30% 100%

Every 8-16 h 100%

Every 8-24 h 100%

Every 6-12 h Every 6 h

Every 8-12 h 100%

Every 12 h 100%

Avoid 100%

Drug

First dose

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