Clinically important bleeding

While the direction of the effect remains the same, there are some differences in results between overt and clinically important bleeding ( Table 1). H2-receptor antagonists remain clearly superior to placebo or no therapy (common odds ratio 0.42, 95 per cent confidence interval 0.21-0.79). Antacids appear to be more efficacious than placebo or no therapy (common odds ratio 0.35, 95 per cent confidence interval 0.08-1.33), although chance must be considered as a possible explanation of the difference.

The trend in favor of H2-receptor antagonists over antacids in overt bleeding also appeared in the analysis of clinically important bleeding (common odds ratio, 0.91; 95 per cent confidence interval, 0.52-1.61). However, the trend in favor of sucralfate over H 2-receptor antagonists in overt bleeding, disappeared for clinically important bleeding (common odds ratio, 1.35; 95 per cent confidence interval, 0.21-9.35). Finally, while antacids and sucralfate appeared equivalent with respect to overt bleeding, a trend in favor of antacids appeared in the pooled analysis of clinically important bleeding (common odds ratio, 1.54; 95 per cent confidence interval, 0.45-5.25). However, the confidence intervals for these comparisons are very wide.

Sleep Apnea

Sleep Apnea

Have You Been Told Over And Over Again That You Snore A Lot, But You Choose To Ignore It? Have you been experiencing lack of sleep at night and find yourself waking up in the wee hours of the morning to find yourself gasping for air?

Get My Free Ebook


Post a comment