Clinical settings associated with brain damage from hyponatremia

Hyponatremia occurs with a similar frequency among men and women, but brain damage occurs predominantly in young (menstruant) females and prepubertal individuals (FraseĀ£.and..Arieff...1990; Ayus..etal, 1992). There are at least two distinct causes of hyponatremic brain damage: hyponatremic encephalopathy, and improper therapy of symptomatic hyponatremia. The vast majority of brain damage from hyponatremia occurs in three clinical settings: the postoperative state; psychogenic polydipsia; patients taking diuretics.

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