Clinical effects

The clinical sequelae of hyperphosphatemia are related to its effects on the serum calcium concentration. When the solubility product of phosphate and calcium is exceeded, calcium phosphate precipitation occurs. This results in ectopic calcification ( Table.?). Mild hyperphosphatemia such as that seen in hyperthyroidism has no obvious clinical effects. However, when a substantial increase in phosphate occurs with a parallel precipitous fall in serum calcium, tetany, hypotension, and even convulsions can occur. Although hypocalcemia commonly parallels hyperphosphatemia, chronic increases in serum phosphate levels may not show these changes (BourkeandYanagawa 1,993).

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Table 2 Clinical sequelae of hyperphosphatemia

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